实验室成员

首页 > 实验室成员 > 谢志

谢志    教授
办公地址:广州先烈南路54号中山眼科中心3号楼402a
电话:020-87335131   邮箱:xiezhi@gmail.com



个人简介

     谢志,教授,临床医学和计算机科学双重学位,中山眼科中心及眼科学国家重点实验室教授、中山大学生物医学大数据中心主任、中山大学学术委员会委员、,2013年回国前任美国国家癌症研究院研究员(Investigator)。2013年入选“千人计划”青年项目。现任广东省生物信息学会理事长、广东省精准医学大数据工程中心执行主任,美国生物信息学ACM会议委员会委员、瑞士《统计遗传学和数学前沿》副主编等。
     主要研究方向为生物信息学和基因表达调控,在《Cell》,《Molecular Systems Biology》,《Nucleic Acids Research》等期刊发表学术论文34篇,总影响因子超过300分,引用>1000次。2014年利用多组学研究发现预测疫苗应答异质性的早期分子标记物(Cell, 2014);2015年开发首个全基因翻译谱数据库,被评为中华医学会 2015年眼科学十大进展(Nucleic Acids Research,2015);2016年开发了首个DNA 6mA甲基化数据库(Nucleic Acids Research,2016)。现主持国家及省市级项目超过2000万元。

研究经历

2013/10 – 至今,中山大学,中山大学眼科中心,教授
2012 – 2013,美国国立癌症研究院 (National Cancer Institute),研究员(Investigator)
2010 – 2012,美国国立健康研究院(National Institutes of Health),Center for Human Immunology,Staff Scientist
2007 – 2010,约翰霍普金斯大学(Johns Hopkins University),眼科研究院 (Wilmer Eye Institute),博士后(Postdoctoral fellow)

教育经历

2004 – 2007,新西兰林肯大学 (Lincoln University),计算系统生物学专业 (Computational Systems Biology),博士
2002 – 2004,新西兰林肯大学(Lincoln University),应用计算专业 (Applied Computing),一级荣誉学士
1993 – 1998,重庆医科大学,临床医学系,临床医学专业,本科

科研成果 (# 共同作者, * 通讯作者)
  1. Chuan-Le Xiao#, *, Ying Chen#, Shang-qian Xie, Kai-Ning Chen, Yan Wang, Feng Luo*, and Zhi Xie*, MECAT: an ultra-fast mapping, error correction, and de novo assembly tool kit for single-molecule sequencing reads, Nature Methods (In Press)
  2. Hongwei Wang#, Yan Wang#, and Zhi Xie, Computational resources for ribosome profiling: from database to web server and software, Briefings in Bioinformatics (In Press)
  3. Hongwei Wang#, Yan Wang#, Shangqian Xie and Zhi Xie*, Global and Cell-type Specific Properties of LincRNAs with Ribosome Occupancy (2016), Nucleic Acids Research, Oct 13. pii: gkw909
  4. Pohao Ye#, Yizhao Luan#, Chuanle Xiao#, Kaining Chen, Yizhi Liu, Zhi Xie*, MethSMRT: an integrative database for DNA N6-methyladenine and N4-methylcytosine generated by single-molecular real-time sequencing (2016), Nucleic Acids Research, Oct 13, doi: 10.1093/nar/gkw950
  5. Xie SQ#, Nie P #, Wang Y #, Wang H, Li H, Yang Z, Liu Y *, Ren J *, Xie Z *. RPFdb: a database for genome wide information of translated mRNA generated from ribosome profiling (2015). Nucleic Acids Res. Oct 3.
  6. Tsang, J. *, Schwartzberg, P. *, Kotliarov, Y. # ,Biancotto, A. #, Xie, Z. #, Germain, R. #, Wang, E. #, Olnes, M. #, Narayanan, M., Golding, H., Moir, S., Dickler, H., Perl, S., Cheung, F., The Baylor HIPC Center, The CHI Consortium, Global analyses of human immune variation reveal baseline predictors of post-vaccination responses (2014). Cell. 157, 499-513
  7. Newman, R.H. #, Hu, J. #, Rho, H.-S. #, Xie, Z. #, Woodard, C., Neiswinger, J., Cooper, C., Shirley, M., Clark, H.M., Hu, S., Hwang, W., Jeong, JS., Wu, G., Lin, J., Gao, X., Ni, Q., Goel, R., Xia, S., Ji, H., Dalby, KN., Birnbaum, MJ., Cole, PA., Knapp, S., Ryazanov, AG., Zack, DJ., Blackshaw, S., Pawson, T., Gingras, AC., Desiderio, S., Pandey, A., Turk, BE., Zhang, J., Zhu, H. *, Qian, J*. Construction of human activity-based phosphorylation networks (2013). Mol. Syst. Biol. 9.
  8. Hu, SH.#, Xie, Z.#,Onishi, A., Yu, X. P., Jiang, L. Z., Lin, J., Rho, H. S., Woodard, C., Wang, H., Jeong, J. S., Long, S. Y., He, X. F., Blackshaw, S., Qian, Q. & Zhu, H. (2009). Profiling the Human Protein-DNA Interactome Reveals ERK2 as a Transcriptional Repressor of Interferon Signalling. Cell. 139(3), 610-622.
  9. Xie, Z.*, Kulasiri, D., Samarasinghe, S. & Qian, J. (2009). An Unbiased Sensitivity Analysis Reveals Important Parameters Controlling Periodicity of Circadian Clock. Biotechnology and Bioengineering. 105(2),250-259
  10. Xie, Z.&Kulasiri, D. (2007). Modelling of Circadian Rhythms in Drosophila Incorporating the Interlocked PER/TIM and VRI/PDP1 Feedback Loops. J. Theor. Biol. 245(2), 290-304
中山大学系统生物学中心 版权所有